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Therefore, the multiple active conformations of GLP-1R, induced by different agonist-binding modes and showed as diverse displacements of NTD, extracellular loops and TM segments, can transduce a common change at the extracellular portion of TM6, which subsequently induces the conformational changes in the intracellular face for Gs binding
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Do not use external heat sources such as warm water, microwave, or direct sunlight, as rapid temperature changes can compromise the medication's integrity
