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Consistent with the neuroanatomical observation that leptin suppresses the density of projections from PPG neurons to the hypothalamus, we also determined that viscerosensory transmission from the gastrointestinal (GI) tract to the PVH is dysregulated
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Peripheral orexigenic mechanisms The major gastrointestinal hormone with potent orexigenic properties is ghrelin (12) which has been identified in gastric ghrelin X/A cells characterized by large eletrodense granules of P/D type in man and A-like type in rats (13)
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