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Some participants in clinical trials have reported difficulty falling or staying asleep, particularly in the early weeks of treatment, though whether this reflects a direct drug effect remains uncertain

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The SUSTAIN cardiovascular outcome trial programme demonstrating significant reduction in major adverse cardiovascular events in type 2 diabetes patients, and the SELECT trial demonstrating cardiovascular event reduction in obese patients without diabetes, have further established Semaglutide as a cardioprotective agent with GLP-1R-mediated cardiovascular biology extending beyond glycaemic and weight management