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First-generation GLP-1 receptor agonists necessitated once or twice-daily dosing, resulting in substantial peak-to-trough variations that caused inconsistent glycaemic regulation and heightened gastrointestinal adverse effects (Nauck and Meier 2019)
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27 In adults with T2D, liraglutide improves beta cell function, as evident by the increase in first-and second-phase insulin secretion
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