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Additionally, inflammatory mediators, including mitochondrial reactive oxygen species (ROS), can stimulate proinflammatory signaling pathways (Jak-STAT, NF-κB, and NLRs) in BECs, pericytes, and astrocytes, potentially damaging the BBB and interfering with the morphogen signaling (Wnt/β-catenin and SHH) as well as transcriptional program of the BECs, leading to NVU breakage
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Conversely, others experience the most intense side effects within the first 24 hours, preferring to sleep through the initial impact
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